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3D Biomatrix Files Patent for Hanging Drop Transfer Plate Technology

7/24/2013 2:03:51 PM

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3D Biomatrix, which develops and sells tools for drug discovery research and testing that mimic the human cellular environment, has filed a patent on a technology for a hanging drop transfer plate. The plate will allow researchers to easily transfer drops containing spheroids from 3D Biomatrix’s Perfecta3D® Hanging Drop Plates to a receiving plate of the researcher’s choice.

3D Biomatrix, a leader in three-dimensional (3D) cell culture products, is pleased to announce that it has filed a patent for its technology for transferring spheroids from the company’s 96-well or 384-well Perfecta3D Hanging Drop Plates to a receiving plate for analysis of the spheroids.

Perfecta3D Hanging Drop Plates facilitate the formation, culture, and testing of 3D spheroids in a well plate format without the aid of coatings or matrices, and without cells coming into contact with plastic. Spheroid cultures grown in Perfecta3D Hanging Drop Plates allow preclinical researchers to easily mimic tissue metabolic and proliferative gradients, capture complex cell-matrix and cell-cell interactions, conduct co-cultures, and monitor cell growth easily and regularly.

Once spheroids form in the Hanging Drop Plates, researchers often want to transfer the 3D micro-tissues to a two-dimensional (2D) receiving plate to image and / or conduct assays. The new transfer plate acts as a funnel to transfer spheroids simultaneously from all wells of the Hanging Drop Plates to the desired receiving plate with a simple step. The receiving plate can be any 2D well plate of the researcher’s choice.

“Our goal is to help researchers save time and money by collecting more biologically relevant data,” said Laura Schrader, CEO of 3D Biomatrix. “Combining our Hanging Drop Plates with the new transfer plates make the entire process, from forming spheroids to their analysis, as easy as possible. Since our 3D cell culture products work with the equipment researchers already have in the lab, researchers no longer feel trapped in buying an entire system to achieve 3D cultures,” she said.

Spheroid formation is controllable and easy with Perfecta3D Hanging Drop Plates. Users simply pipet a cell suspension into each channel; the channel shape causes the drop to securely hang from the bottom of the well. As cells do not contact any surfaces, they aggregate into a spheroid. One spheroid forms per well, and the spheroid diameter is controlled by the cell type and number of cells added to each well. Media and compounds can be added or removed from the top of the plate without requiring new equipment, and cells can be added for co-cultures.

Information about the Perfecta3D Hanging Drop Plates and news on the release of the transfer plate can be found on the 3D Biomatrix website.

About 3D Biomatrix
3D Biomatrix is a life sciences company offering revolutionary easy-to-adopt solutions for three dimensional (3D) cell cultures used for drug discovery, cancer, and stem cell research and testing. Cells grown with 3D Biomatrix products mimic the high complexity of the human cellular environment more than cells grown in traditional two-dimensional plates and flasks.

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