Blue Heron Biotechnology Awarded Grant For Universal Restriction Enzyme And Large DNA Fragment Assembly
10/19/2005 5:10:10 PM
Blue Heron Biotechnology, Inc. announced today that it has been awarded a Phase I Small Business Innovative Research (SBIR) grant from the National Institute of General Medical Science (NIGMS) and the National Human Genome Research Institute (NHGRI). The $137,910 grant will fund research to develop a "universal" restriction enzyme system. The goal of the grant is to develop a uniform method for assembling large DNA molecules by ligation of sticky-ended fragments, regardless of the sequence, the fragment length, or the presence of restriction sites. If successful, it will enable the use of restriction digestion to release any cloned fragment and allow complete control of the sticky ends on these fragments. This "universal cutter" will support the reliable assembly of DNA fragments of 100,000 base pairs or larger and allow Blue Heron Bio to extend its GeneMaker(R) gene synthesis service to include large genomic DNA fragments and bacterial genomes. Moreover, the technology will increase GeneMaker's efficiency for the shorter genes, e.g., 1,000 to 5,000 base pairs, which most researchers study.
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