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Paracel Announces Three New GeneMatcher2(TM) Customers

10/19/2005 5:08:51 PM

Nestlé Research Center, Switzerland, University of Wuerzburg, Germany and Institute of Molecular Pathology, Austria Choose Paracel GeneMatcher2 to Support Computational Biology Infrastructure

PASADENA, Calif. - June 29, 2004 - Paracel, Inc.®, a business unit of the Celera Genomics Group of Applera Corporation and a leading provider of applied high-performance computing(TM) solutions, today announced that the Nestlé Research Center, the University of Wuerzburg and the Institute of Molecular Pathology have chosen GeneMatcher2 to support their bioinformatics research. Combining specialized ASIC accelerators with a state-of-the-art Linux cluster, GeneMatcher2 is a complete system for rigorous sequence analysis. Due to the flexibility and scalability of its design, research institutions worldwide are choosing the GeneMatcher2 to support a variety of research areas including RNAi, comparative genomics and genome annotation.

Through its unique architecture, GeneMatcher2 makes previously impossible searches achievable. For example, Paracel completed an exhaustive comparison of the human X chromosome to human Y chromosome in less than 11 hours by running Smith-Waterman on GeneMatcher2. The GeneMatcher2 includes over 10 dynamic search algorithms including Smith-Waterman, Hidden Markov Models (HMMs) and GeneWise and nine varieties of optimized BLAST.

With the integrated Paracel Cyclone Linux cluster, one GeneMatcher2 system can support an entire life science infrastructure including applications for bioinformatics, computational chemistry and molecular modeling. These recently installed systems incorporate AMD Opteron(TM) processors as part of the cluster to give researchers access to 32- and 64-bit computing capabilities.

The Nestlé Research Center (, which is already using the Paracel BlastMachine2(TM), has added the GeneMatcher2 to further increase its genomic research capability. Incorporating the GeneMatcher2 into their existing infrastructure enables the center to run algorithms that can provide more sensitivity and perform a broader set of bioinformatics research tasks.

The University of Wuerzburg ( purchased the GeneMatcher2 for research in functional genome analysis and comparative genomics including pathogenomics. "With the computational demands of our research, we required a system that could run complex dynamic programming search algorithms, such as Hidden Markov Models, quickly and reliably," said professor Thomas Dandekar, University of Wuerzburg. "The GeneMatcher2 allows us to perform high-throughput screening around the clock. This has improved both the scope and the efficiency of our research by enabling searches that would be impossible to run on other systems."

The Institute of Molecular Pathology in Vienna, Austria ( is equipping its Bioinformatics Group (, headed by Frank Eisenhaber, with a GeneMatcher2 system. This group is engaged in multiple collaborations with experimental life science research teams. The interaction regularly involves in-depth in silico characterization of thousands of biomolecular sequences per year as well as genome-wide searches for relevant gene targets in eukaryote model organisms. In addition to running HMMs and Paracel BLAST(TM), the Bioinformatics Group is integrating Paracel's GeneMatcher2 into "ANNIE", a sophisticated genome annotation platform that they have been developing.

"The bioinformatics field is growing rapidly in Europe. Research institutions require a high performance computing infrastructure that is tailored to their research environment," said Jason Mollé, president of Paracel. "With our ability to leverage a decade of life science expertise we can support facilities worldwide, from pre-configuration of a system to providing one point of contact for support of the hardware, OS, middleware and integrated applications."

About Paracel GeneMatcher2

The Paracel GeneMatcher2 is a massively parallel supercomputer designed to accelerate dynamic programming algorithms for genomic analysis including Smith-Waterman, HMMs and GeneWise. In addition, GeneMatcher2 incorporates optimized Paracel BLAST(TM), so that one system allows access to all commonly used sequence analysis algorithms. Customized ASIC hardware accelerates dynamic programming algorithms and an integrated Paracel Cyclone Linux cluster provides a HPC computing infrastructure to support additional life science applications.

GeneMatcher2 is a turnkey system - pre-configured with all necessary hardware and software, pre-tested for a minimum of 72 hours, and installed by Paracel's engineers. The GeneMatcher2 also includes one year of premium support for all hardware, middleware and software, including 24x7 phone and e-mail support and on-site service.

About Paracel, Inc.

Paracel ( is a leading provider of applied high-performance computing solutions to solve the most technically challenging problems. Founded in 1992 to commercialize high-volume data analysis technology, Paracel today is a premier provider of integrated turnkey systems and software for over 500 customers worldwide. Paracel is headquartered in Pasadena, California and is a wholly-owned subsidiary of Celera Genomics.

Paracel GeneMatcher2, Paracel Cyclone, Paracel BLAST and Paracel are trademarks and registered trademarks of Paracel, Inc. All other trademarks are property of their respective owners.


Amanda Sheldon

Paracel, Inc.

(626) 744-2086

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