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GeneMax Corp. (GMXX.OB) Announces Publication Demonstrating The Efficacy Of A New Vector System In Treatment Of Models Of Lung Cancer


10/19/2005 5:09:12 PM

VANCOUVER, Sept. 6 /PRNewswire-FirstCall/ - GeneMax Corp. , a biotechnology company specializing in the development of immunotherapeutics for cancer and vaccines for infectious diseases, announced today that a scientific paper co-authored by the Company's Chief Scientific Officer, Dr. Wilfred Jefferies, and his research collaborators from the University of British Columbia and another international institution, has been published in Cancer Research (Sept. 1, 2005 vol. 65 no.17, pages, 7926-7933), the journal of the American Association for Cancer Research. The paper http://cancerres.aacrjournals.org/cgi/content/abstract/65/17/7926 entitled "Restoration of the Expression of Transporters Associated with Antigen Processing in Lung Carcinoma Increases Tumor-Specific Immune Responses and Survival", describes the use of AdhTAP1, an adenovirus containing TAP1 cDNA, to increase the immune response and survival in animal models of lung cancer.

"We have demonstrated that the down-regulation of TAP1 occurs in a wide variety of human lung cancers, and that the corresponding defect in the antigen processing pathway can be reversed using an adenovirus containing TAP1 cDNA," said Dr. Wilfred A. Jefferies. "In an animal model with a lung carcinoma lacking TAP1, the antigen processing was enhanced, leading to tumour specific immune responses and greatly increased animal survival. These data provide critical proof of concept of the type of vectoral systems we plan to take into the clinic."

The investigators assessed human lung cancer biopsy samples (nine small cell and 10 non-small cell carcinomas) for expression of components of the antigen processing pathway (APP) and found only one of the 19 samples expressed normal levels of TAP1. The restoration of TAP1 expression was investigated using a non-replicating adenovirus AdhTAP1 and the mouse lung cancer cell line, CMT.64, which is equivalent to aggressive human carcinomas and has a deficient APP. In ex vivo experiments, AdhTAP1 treatment of CMT.64 resulted in restoration of antigen presentation on the surface of the cancer cells. In addition, AdhTAP1 treatment of dendritic cells (DCs), critical components of the cellular immune response, increased the antigen presenting capabilities of the DCs. Ex vivo treatment resulted in 100% survival of animals receiving the AdhTAP1 modified tumours compared to 100% mortality for the placebo groups. Studies were also conducted in mouse models in which CMT.64 cells were injected into the peritoneal cavity, followed by various treatments. When tumors were treated in vivo with AdhTAP1, also delivered into the peritoneal cavity, mice showed an increased median survival to 68 days, compared to 22 and 25 days for two placebo groups, and showed a 35% cure rate (greater than 100 days), compared to 100% mortality within 48 days in the placebo groups.

About TAP

Transporters Associated with Antigen Processing (TAP) are ABC transporters responsible for supplying tumor-associated antigens and viral antigens used in the assembly of MHC class I surface molecules. MHC class I molecules are required for the recognition and destruction of tumor cells and virus infected cells by the cellular arm of the immune system. A wide variety of metastatic cancers evade destruction by the immune system due to absent or insufficient amounts of TAP, making the tumors unrecognizable by the immune system.

About GeneMax Corp.

GeneMax Corp. is a biotechnology company specializing in the development of innovative therapeutics and vaccines in the areas of oncology and infectious disease. The companies' lead product, the AdhTAP(OS-1) vaccine enhancer restores and augments antigen presentation and subsequent recognition and killing of cancer cells by the immune system. The company is currently in pre-clinical development in anticipation of a phase I clinical trial.

Stock Exchange Information: (Symbol: GMXX-(OTCBB)

SAFE HARBOR STATEMENT

THIS NEWS RELEASE INCLUDES FORWARD-LOOKING STATEMENTS WITHIN THE MEANING OF SECTION 27A OF THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED, AND SECTION 21E OF THE UNITED STATES SECURITIES AND EXCHANGE ACT OF 1934, AS AMENDED. THESE STATEMENTS ARE MADE UNDER THE "SAFE HARBOR" PROVISIONS OF THE UNITED STATES PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995. EXCEPT FOR THE HISTORICAL INFORMATION PRESENTED HEREIN, MATTERS DISCUSSED IN THIS PRESS RELEASE CONTAIN FORWARD-LOOKING STATEMENTS THAT ARE SUBJECT TO CERTAIN RISKS AND UNCERTAINTIES THAT COULD CAUSE ACTUAL RESULTS TO DIFFER MATERIALLY FROM ANY FUTURE RESULTS, PERFORMANCE OR ACHIEVEMENTS EXPRESSED OR IMPLIED BY SUCH STATEMENTS. STATEMENTS THAT ARE NOT HISTORICAL FACTS, INCLUDING STATEMENTS THAT ARE PRECEDED BY, FOLLOWED BY, OR THAT INCLUDE SUCH WORDS AS "ESTIMATE," "ANTICIPATE," "BELIEVE," "PLAN" OR "EXPECT" OR SIMILAR STATEMENTS ARE FORWARD-LOOKING STATEMENTS. RISKS AND UNCERTAINTIES FOR GENEMAX CORP. INCLUDE BUT ARE NOT LIMITED TO THE RISKS ASSOCIATED WITH PRODUCT DISCOVERY AND DEVELOPMENT AS WELL AS THE RISKS SHOWN IN GENEMAX'S MOST RECENT ANNUAL REPORT ON FORM 10-KSB AND ON FORM 10-QSB AND FROM TIME-TO-TIME IN OTHER PUBLICLY AVAILABLE INFORMATION REGARDING GENEMAX. OTHER RISKS INCLUDE RISKS ASSOCIATED WITH OBTAINING GOVERNMENT GRANTS, THE SUCCESS OF PRECLINICAL AND CLINICAL TRIALS, THE PROGRESS OF RESEARCH AND PRODUCT DEVELOPMENT PROGRAMS, THE REGULATORY APPROVAL PROCESS, COMPETITIVE PRODUCTS, FUTURE CAPITAL REQUIREMENTS, AND GENEMAX'S ABILITY AND LEVEL OF SUPPORT FOR ITS RESEARCH ACTIVITIES. THERE CAN BE NO ASSURANCE THAT GENEMAX'S DEVELOPMENT EFFORTS WILL SUCCEED, THAT SUCH PRODUCTS WILL RECEIVE REQUIRED REGULATORY CLEARANCE, OR THAT EVEN IF SUCH REGULATORY CLEARANCE WERE RECEIVED, THAT SUCH PRODUCTS WOULD ULTIMATELY ACHIEVE COMMERCIAL SUCCESS. GENEMAX DISCLAIMS ANY INTENT OR OBLIGATIONS TO UPDATE THESE FORWARD-LOOKING STATEMENTS.

GeneMax Corp.

CONTACT: Nick Hurst, The Equicom Group Inc., Tel: (416) 815-0700 or1-800-385-5451 ext. 226, Fax: (416) 815-0080, nhurst@equicomgroup.com



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